Amiloride-Sensitive Sodium Channels: Physiology And Functional Diversity; Author: Benos, Dale J.; Joint Author: Fambrough, Douglas M.; Paperback

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Amiloride-Sensitive Sodium Channels: Physiology And Functional Diversity

Author: Benos, Dale J.; Joint Author: Fambrough, Douglas M.
Paperback
400 pages
Published: October 1999
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd
ISBN: 0120890305

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium-regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulatio

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